TReatment Approaches and bIomarkers preValence in bladdEr Cancer in RuSsian Federation

Recruiting now

Conditions studied: Bladder Cancer

In brief

A multicentre observational study on treatment approaches and HER2 positive status prevalence in different stages of bladder cancer and PD-L1-positive status in metastatic bladder cancer in Russian Federation

Key facts

Study ID

NCT07038928

Run by

AstraZeneca

People needed

600

Starts

2025-06-30

Expected to finish

2026-12-31

Last updated by the study team

2026-08-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years;
• Signed ICF, including consent for FFPE tumor tissue sample testing;
• Confirmed diagnosis of urothelial bladder cancer at NMIBC, MIBC, or mBC stage at study entry;
• For patients with NMIBC: 1. TURBT performed at least 1 month but not more than 12 months prior to study entry; 2. Presence of ≥1 high-risk feature:
• T1 tumor
• High grade/G3 tumor
• CIS (carcinoma in situ)
• Multiple and recurrent and large (with diameter of largest tumor ≥3 cm) tumors (all conditions must be met in this point);
• For patients with MIBC: Сystectomy performed at least 2 months but not more than 12 months prior to study entry;
• For patients with mBC: mBC diagnosed during 12 months prior to study entry;
• Availability of medical history data;
• Availability of FFPE tumour tissue sample obtained during biopsy and/or surgery.

You may not qualify if…

• Participation in any interventional trial since the urothelial bladder cancer diagnosis.

Where it is running

• Research Site — Arkhangelsk, Russia (enrolling)
• Research Site — Barnaul, Russia (enrolling)
• Research Site — Chelyabinsk, Russia (enrolling)
• Research Site — Krasnodar, Russia (enrolling)
• Research Site — Krasnoyarsk, Russia (enrolling)
• Research Site — Makhachkala, Russia (enrolling)
• Research Site — Moscow, Russia (enrolling)
• Research Site — Omsk, Russia (enrolling)
• Research Site — Saint Petersburg, Russia (enrolling)
• Research Site — Tomsk, Russia (enrolling)
• Research Site — Tyumen, Russia (enrolling)
• Research Site — Ufa, Russia (enrolling)
• Research Site — Yekaterinburg, Russia (enrolling)
• Research Site — Nizhny Novgorod, Russia (enrolling)
• Research Site — Moscow, Russia
• Research Site — Moscow, Russia
• Research Site — Saint Petersburg, Russia
• Research Site — Novosibirsk, Russia
• Research Site — Obninsk, Russia
• Research Site — Saint Petersburg, Russia

Full record on ClinicalTrials.gov

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