A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Obesity, Overweight, Chronic Low Back Pain (CLBP)

In brief

The main purpose of this study is to evaluate the efficacy and safety of retatrutide in relieving chronic low back pain in participants who have obesity or overweight. Participation in the study will last about 80 weeks.

Key facts

Study ID

NCT07035093

Run by

Eli Lilly and Company

People needed

586

Starts

2025-05-29

Expected to finish

2027-09-01

Last updated by the study team

2026-07-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a history of axial-predominant low back pain
• Have pain that is restricted to the low back or with a referral pattern limited to the proximal legs
• Have a body mass index (BMI) ≥27 kilograms per square meter (kg/m2) at screening
• Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight

You may not qualify if…

• Have a non-axial origin low back pain
• Have had botulinum or steroid injections to the spine within 1 year of screening
• Have had trigger point injection to the spine within 6 months of screening
• Have a self-reported change in body weight >5 kilograms (kg) (11 pounds) within 90 days prior to screening
• Have been taking drugs to promote body weight reduction, including over-the-counter medications, within 90 days prior to screening
• Have a prior or planned surgical treatment for obesity
• Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes

Where it is running

• MD First Research - Chandler — Chandler, Arizona, United States
• Tucson Orthopaedic Institute - North Wyatt Drive — Tucson, Arizona, United States
• Ark Clinical Research - Fountain Valley — Fountain Valley, California, United States
• St Joseph Heritage Healthcare — Fullerton, California, United States
• Clinical Research Institute — Los Angeles, California, United States
• Artemis Institute for Clinical Research — San Diego, California, United States
• Alpine Clinical Research Center — Boulder, Colorado, United States
• K2 Medical Research - Daytona Beach — Daytona Beach, Florida, United States
• Flourish Research - Miami, LLC — Miami, Florida, United States
• IMA Clinical Research St. Petersburg — St. Petersburg, Florida, United States
• Care Access - Tampa — Tampa, Florida, United States
• Charter Research - Lady Lake — The Villages, Florida, United States
• Conquest Research — Winter Park, Florida, United States
• Cotton O'Neil Clinical Research Center — Topeka, Kansas, United States
• Care Access - Lake Charles (Bayou Pines) — Lake Charles, Louisiana, United States
• MedVadis Research Corporation — Waltham, Massachusetts, United States
• Great Lakes Research Group, Inc. — Bay City, Michigan, United States
• Clinvest Headlands Llc — Springfield, Missouri, United States
• Center for Clinical Research — Winston-Salem, North Carolina, United States
• Altoona Center For Clinical Research — Duncansville, Pennsylvania, United States
• New Phase Research and Development — Knoxville, Tennessee, United States
• FutureSearch Trials of Neurology — Austin, Texas, United States
• Mercy Family Clinic — Dallas, Texas, United States
• Houston Research Institute — Houston, Texas, United States
• Sovah Clinical Research-River District — Danville, Virginia, United States

Full record on ClinicalTrials.gov

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