Evaluating Benzoyl Peroxide for Preventing Recurrence of HSV-1 Outbreaks With Rescue Crossover Option

Starting soon · Phase 2 · Has a placebo group

Conditions studied: HSV

In brief

Here's a clear, concise, and accurate \*\*brief summary\*\* suitable for your ClinicalTrials.gov PRS submission: * Brief Summary: This randomized, double-blind, placebo-controlled clinical trial evaluates the effectiveness of topical Benzoyl Peroxide (10%) in preventing recurrent oral lesions caused by Herpes Simplex Virus Type 1 (HSV-1). Participants who experience frequent HSV-1 outbreaks will be randomly assigned to either Benzoyl Peroxide or placebo treatment. The trial will be conducted via telehealth visits, with treatment provided remotely. The primary objective is to determine whether Benzoyl Peroxide significantly delays or prevents HSV-1 lesion recurrence compared to placebo. Secondary outcomes include evaluating recurrence frequency, lesion severity, healing duration, and participant satisfaction. The trial also incorporates a rescue crossover step, allowing placebo-group participants who experience recurrence to receive active treatment. Results from this pilot study will inform the potential use of Benzoyl Peroxide as a novel, accessible topical treatment option for recurrent HSV-1 outbreaks.

Key facts

Study ID

NCT07032649

Run by

Greg Bew

People needed

100

Starts

2026-01-01

Expected to finish

2027-07-01

Last updated by the study team

2025-08-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18-65 years, inclusive.
• Documented history of at least two HSV-1 outbreaks per year.
• Ability and willingness to participate fully via telehealth (including video visits).
• Must provide informed consent to participate in the trial.
• Ability to comply with the trial protocol, including symptom reporting, topical cream application, and follow-up telehealth appointments.

You may not qualify if…

• Currently pregnant or breastfeeding, or plans to become pregnant during the study period.
• Known allergy or sensitivity to benzoyl peroxide or similar topical agents.
• Current participation in another clinical trial involving topical treatments.
• Medical conditions or skin conditions that could significantly interfere with topical treatment application or safety assessment.
• Inability to effectively participate in telehealth visits or use video-based symptom verification.
• Participants who, in the opinion of the investigator, are unlikely to comply fully with trial requirements or complete the 6-month follow-up period.

Where it is running

• Zoom Health, Telehealth Only — Evans, Georgia, United States

Full record on ClinicalTrials.gov

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