Regenerative Outcomes for Peri-implant Bony Defects Using Amnion-chorion Barrier vs. Collagen Membrane
Starting soon · Not applicable
Conditions studied: Peri-Implantitis
In brief
The purpose of this study is to compare the clinical and radiographic outcomes of two different barrier membranes-amnion-chorion membranes (ACM) and conventional collagen membranes-used in guided bone regeneration (GBR) procedures for the treatment of peri-implantitis. Both membranes are commonly used in clinical practice; however, this study aims to determine whether ACM offers greater benefits in terms of peri-implant probing depth reduction, radiographic bone fill, and patient-reported post-operative healing outcomes. The findings may help inform surgical decision-making and support the use of ACM as a more effective regenerative material for managing peri-implant bony defects.
Key facts
- Study ID
- NCT07032259
- Run by
- Loma Linda University
- People needed
- 56
- Starts
- 2026-12-01
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-07-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Systemically healthy adults (≥18 years) with a diagnosed peri-implantitis lesion requiring surgical intervention of any ethnicity
- Comprehension of treatment plan and research project.
- Presence of a single implant in function for at least one year.
- Radiographic evidence of peri-implant bone loss not exceeding one-third of the implant length.
- 2-3 wall defects amenable to guided bone regeneration (GBR).
- Screw-retained, posterior, self-cleansing implant prosthesis.
- Commitment to maintaining oral hygiene and attending follow-up visits.
You may not qualify if…
- Patients who have had a history of periodontitis, diabetes, smoking habit, or have been prescribed medications that may interfere with bone healing and metabolism
- Patients with allergies to any treatment devices
- Patients who have a lack of keratinized mucosa (<2 mm), or positioning for implants or restorative designs that compromise oral hygiene
- Peri-implant bone defects not attributable to peri-implantitis (e.g. surgical iatrogenic, trauma)
- Anterior implant restorations (#'s 6-11, #'s 22-27) or cement-retained restorations
Full record on ClinicalTrials.gov
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