Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity

Recruiting now · Not applicable

Conditions studied: Obesity

In brief

The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific cannulation of the superior epigastric vein. We will characterize the exosome signatures in response to a meal and compare to the exosome signature of arterialized venous plasma samples.

Key facts

Study ID

NCT07031297

Run by

Mayo Clinic

People needed

20

Starts

2026-05-05

Expected to finish

2028-05-01

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All women must be premenopausal

You may not qualify if…

• Participants taking medications know to affect blood flow (statins, β-blockers) or fatty acid or adipose tissue metabolism (TZDs, high dose fish oil supplements)
• Diabetes, history of cardiovascular disease
• Allergy to lidocaine
• Post-menopausal women
• Pregnant

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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