A Study of LY3549492 in Adults With Obesity or Overweight With Type 2 Diabetes

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Obesity, Overweight, Type 2 Diabetes

In brief

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to evaluate the effects of treatment with LY3549492 compared to placebo in adult participants with obesity or who are overweight with type 2 diabetes. Participation in the study will last about 11 months.

Key facts

Study ID

NCT07030868

Run by

Eli Lilly and Company

People needed

1

Starts

2025-06-19

Expected to finish

2025-07-29

Last updated by the study team

2025-08-29

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• W8M-MC-GN02:
• Assigned male at birth
• Assigned female at birth, who are of non-childbearing potential
• Have type 2 diabetes
• W8M-MC-CWMM:
• Have a BMI ≥27 kilograms per square meter (kg/m²)
• Have had a stable body weight for the 3 months prior to randomization (<5% body weight gain and/or loss

You may not qualify if…

• W8M-MC-GN02:
• Individuals who are of childbearing potential
• Have a history of acute or chronic pancreatitis
• Have any of the following cardiovascular conditions within 6 months prior to screening:
• acute myocardial infarction
• cerebrovascular accident (stroke)
• unstable angina, or
• hospitalization due to congestive heart failure.
• W8M-MC-CWMM:
• Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening
• Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma
• Have poorly controlled hypertension
• Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease
• Have a history of symptomatic gallbladder disease within the past 2 years
• Have a lifetime history of suicide attempts

Where it is running

• HOPE Research Institute — Phoenix, Arizona, United States
• Headlands Research - Scottsdale — Scottsdale, Arizona, United States
• NorCal Medical Research, Inc — Greenbrae, California, United States
• Velocity Clinical Research, Huntington Park — Huntington Park, California, United States
• Peninsula Research Associates — Rolling Hills Estates, California, United States
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States
• Stamford Therapeutics Consortium — Stamford, Connecticut, United States
• Northeast Research Institute (NERI) — Fleming Island, Florida, United States
• Indago Research & Health Center, Inc — Hialeah, Florida, United States
• New Horizon Research Center — Miami, Florida, United States
• Suncoast Clinical Research, Inc. — New Port Richey, Florida, United States
• Charter Research - Winter Park — Orlando, Florida, United States
• Charter Research - Lady Lake — The Villages, Florida, United States
• Medical Research Partners — Ammon, Idaho, United States
• Great Lakes Clinical Trials - Ravenswood — Chicago, Illinois, United States
• Iowa Diabetes and Endocrinology Research Center — West Des Moines, Iowa, United States
• Cotton O'Neil Diabetes & Endocrinology — Topeka, Kansas, United States
• Knownwell — Needham, Massachusetts, United States
• Lucida Clinical Trials — New Bedford, Massachusetts, United States
• Headlands Research - Detroit — Southfield, Michigan, United States
• Arcturus Healthcare , PLC, Troy Internal Medicine Research Division — Troy, Michigan, United States
• Clinvest Headlands Llc — Springfield, Missouri, United States
• Las Vegas Medical Research — Las Vegas, Nevada, United States
• Velocity Clinical Research, Syracuse — East Syracuse, New York, United States
• Rochester Clinical Research, LLC — Rochester, New York, United States

Full record on ClinicalTrials.gov

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