The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP
Recruiting now
Conditions studied: Postoperative Acute Kidney Injury, Frailty
In brief
The primary objectives of study is to compare the difference in the incidence of postoperative AKI between frail and non-frail patients. The secondary objectives of study was to compare the differences in intraoperative blood pressure fluctuations, the incidence and duration of intraoperative hypotension, postoperative extubation time, postoperative complications, length of hospital stay and hospitalization expenses between frail and non-frail patients, and use mediating effect analysis to examine the magnitude of the effect of intraoperative blood pressure on postoperative acute kidney injury caused by frailty.
Key facts
- Study ID
- NCT07030179
- Run by
- Lanyue Zhu
- People needed
- 1000
- Starts
- 2025-07-01
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-04-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years old or above
- Undergo non-cardiac surgery
You may not qualify if…
- At least one measurement of serum creatinine (SCr) was not conducted before and after the operation
- End-stage renal disease (ESRD) that has received dialysis within the past year
- Baseline SCr ≥ 4.5 mg/dl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients)
- Acute kidney injury occurred within 7 days before the operation
- No frailty assessment was conducted
- The surgical procedure is renal surgery
- The operation time is less than 2 hours
Where it is running
- Zhongda Hospital Southeast University — Nanjing, Jiangsu, China (enrolling)
Full record on ClinicalTrials.gov
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