Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy

Recruiting now · Not applicable

Conditions studied: Pregnancy, Periodontal Disease, Gingivitis, Dental Plaque, Probiotics, Coenzyme Q10, Microbiota

In brief

This randomized controlled clinical trial aims to evaluate the effectiveness of adjunctive coenzyme Q10 and probiotic supplementation (Limosilactobacillus reuteri Prodentis®) in improving periodontal health in pregnant women undergoing non-surgical periodontal therapy. Forty participants will be randomly assigned to two groups: the test group will receive professional oral hygiene every three months along with a coenzyme Q10-based toothpaste and daily probiotic supplementation; the control group will follow the same protocol without probiotics. The primary outcome is the reduction of the Plaque Index (PI), while secondary outcomes include Bleeding on Probing (BoP), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), gingival inflammation (MGI, PMGI), plaque distribution (PCR%, API), and gingival recession (R). The study duration is 6 months. The goal is to assess whether this combined therapy can promote a balanced oral microbiota and enhance periodontal health during pregnancy.

Key facts

Study ID

NCT07029360

Run by

University of Pavia

People needed

40

Starts

2025-07-01

Expected to finish

2026-06-10

Last updated by the study team

2026-02-20

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Pregnant women between the 4th and 8th month of gestation
• Age ≥ 18 years
• Able to understand and communicate in Italian and/or English
• Willing to provide written informed consent
• Good compliance and willingness to follow study instructions

You may not qualify if…

• Presence of cardiac pacemakers
• Diagnosed psychological, neurological, or psychiatric disorders
• Ongoing oncological therapy
• Use of bisphosphonates within the last 12 months
• Poor motivation or low compliance
• Substance abuse (drugs or alcohol) or lifestyle incompatible with study requirements

Where it is running

• Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia — Pavia, Lombardy, Italy (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.