Early Luteal Phase Progesterone Kinetics After hCG-Induced Ovulation in Modified Natural Cycle
Recruiting now · Not applicable
Conditions studied: Luteal Phase Insufficiency
In brief
This pilot study evaluates how progesterone levels change after hCG-triggered ovulation in modified natural cycles. Forty women preparing for frozen embryo transfer will have blood tests over 6 days to monitor hormone levels. The goal is to understand whether hCG affects the timing of the luteal phase and embryo implantation.
Key facts
- Study ID
- NCT07028710
- Run by
- University Hospital, Montpellier
- People needed
- 40
- Starts
- 2026-01-12
- Expected to finish
- 2030-06-15
- Last updated by the study team
- 2026-06-22
Who can join
Age: any. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- At least 1 follicle of 14 mm or more
- Endometrium of 6 mm or more
- Plasma luteinizing hormone (LH) less than 2 times basal level (measured at the beginning of the cycle between D1 and D4) and progesteronemia less than 1.5 ng/mL
- For whom ovulation induction with recombinant hCG (Ovitrelle) is then proposed (standard care).
You may not qualify if…
- Patient whose venous capital contraindicates repeated blood sampling over a short period of time over a short period.
- Patient treated with exogenous natural progesterone (vaginal or injectable) which may interfere or synthetic progesterone, which may interfere with endogenous progesterone secretion.
- Patient who has not given written consent to participate in the study.
- Patient not fluent in French.
- Patient under guardianship, curators or without social security coverage.
- Patient participating in another study with an ongoing exclusion period or other interventional research with no ongoing exclusion period involves the use of a drug or procedure capable of altering progesterone levels .
Where it is running
- Hôpital Arnaud de Villeneuve — Montpellier, France (enrolling)
Full record on ClinicalTrials.gov
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