Levagen+ Efficacy Study on Diabetic Peripheral Neuropathy

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Diabetic Peripheral Neuropathy

In brief

The goal of this clinical trial is to assess the efficacy of Levagen+ supplementation for the symptoms of diabetic peripheral neuropathy (DPN) in patients with DPN. Participants will have remote visits and attend a local pathology centre for blood draws. They will take the study product for 12 weeks, from baseline to week 12 they will have remote visits every 3 weeks.

Key facts

Study ID: NCT07028528
Run by: RDC Clinical Pty Ltd
People needed: 80
Starts: 2025-07-01
Expected to finish: 2026-05-01
Last updated by the study team: 2025-07-23

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adults aged 18-75 years.
Using prescribed glucose-lowering medications, including oral medications (stable dose for 3 months or more) and/or insulin for diabetes (type 1 or 2).
Scoring12 or more on the Self-reported Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS).
Able to provide informed consent.
Agree not to change current diet and/or exercise frequency or intensity during entire enrolment period.
Agree to not participate in another clinical trial during the study period.
Able to attend an ACL collection centre.

You may not qualify if…

Peripheral neuropathy due to causes other than diabetes mellitus (e.g. nutritional deficiencies; hereditary sensory neuropathy; paraneoplastic diseases; advanced liver disease; kidney disease; hypothyroidism; prolonged phenytoin, warfarin or immunosuppressive drug use; active infection [HIV, Lyme disease, Epstein-Barr virus, Hepatitis C, Shingles, Leprosy]; autoimmune disease [Sjogren syndrome, Lupus, Rheumatoid arthritis, Guillain-Barre syndrome]; trauma / injury; toxins [heavy metals, chemicals]; antibiotics; or inflammatory conditions [vasculitis]).
Serious illness e.g., paraneoplastic diseases, advanced liver disease, kidney disease, hypothyroidism, mood disorders such as depression, anxiety or bipolar disorder, neurological disorders such as MS, or heart conditions, or peripheral vascular disease
Unstable illness e.g., diabetes and thyroid gland dysfunction, hypercholesterolemia
Current malignancy (excluding Basal Cell Carcinoma) or chemotherapy or radiotherapy treatment for malignancy within the previous 2 years.
Currently taking Coumadin (Warfarin), Heparin, Dalteparin, Enoxaparin or other anticoagulation therapy including low dose aspirin
Herbal medicines for pain relief including, but not limited to, medicinal cannabis, willow bark (Salix alba), Boswellia (Boswellia serrata) or turmeric/curcumin (Curcuma longa).
Active smokers, nicotine use or drug (prescription or illegal substances) abuse.
Chronic past and/or current alcohol use (>14 alcoholic drinks per week)
Females attempting to conceive, pregnant or lactating
Allergic, sensitive or intolerant to any of the ingredients in active or placebo formula.
Difficulty swallowing capsules.
Participants who are currently participating in any other clinical trial or who have participated in any other clinical trial during the past 1 month.
Any condition which in the opinion of the investigator makes the participant unsuitable for inclusion.

Where it is running

RDC Clinical — Fortitude Valley, Queensland, Australia (enrolling)

Full record on ClinicalTrials.gov

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