Prospective External Control Cohort In Patients With Newly Diagnosed Advanced or Metastatic EGFR Mutant Non-Small Cell Lung Cancer
Recruiting now
Conditions studied: Non Small Cell Lung Cancer
In brief
The objective of this study is to build a prospective cohort in patients with locally advanced or metastatic NSCLC with common EGFR mutations. In NPM-002, there will be standardized data collection at baseline, on-treatment and at discontinuation of therapy. Patients who enroll prior to initiation of osimertinib treatment (\~30%) will undergo imaging with standardized intervals.
Key facts
- Study ID
- NCT07028489
- Run by
- N-Power Medicine
- People needed
- 130
- Starts
- 2025-06-05
- Expected to finish
- 2029-04-01
- Last updated by the study team
- 2026-07-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Be ≥18 years of age at the time of informed consent
- Evidence of a confirmed diagnosis of EGFR mutant (EGFR exon 19del or EGFR exon 21 L858R) locally advanced or metastatic NSCLC diagnosed on Jan 1st 2024 or later.
You may not qualify if…
- ECOG≥2 at diagnosis of advanced or metastatic NSCLC
- Evidence of prior treatment with osimertinib, amivantamab or lazertinib. For the planned selection and analysis of external controls, further eligibility criteria will be applied according to the COPERNICUS SAP.
Where it is running
- Oncology Consultants, P.A. — Houston, Texas, United States (enrolling)
- Torrance Memorial Physician Network-Cancer Care — Torrance, California, United States (enrolling)
- John Muir Health — Walnut Creek, California, United States (enrolling)
- Bayhealth Cancer Center- Kent — Dover, Delaware, United States (enrolling)
- Bayhealth Cancer Center- Sussex — Milford, Delaware, United States (enrolling)
- Kootenai Clinic Cancer Services Coeur d'Alene — Coeur d'Alene, Idaho, United States (enrolling)
- Northwest Oncology & Hematology — Elk Grove Village, Illinois, United States (enrolling)
- Pacific Cancer Care — Monterey, California, United States (enrolling)
- Lankenau Medical Center — Paoli, Pennsylvania, United States
Full record on ClinicalTrials.gov
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