Acute Treatment and Long-term Assessment of Adult Infectious Meningitis

Recruiting now

Conditions studied: Viral Meningitis, Bacterial Meningitis, Fungal Meningitis, Meningitis

In brief

Prospective, multicenter, observational clinical registry of adult patients with acute infectious meningitis across approximately 30 public and private hospitals in Brazil. The study will include adults, 18 years old and older, with suspected acute infectious meningitis. Data will be collected during hospitalization and post-discharge to evaluate clinical management, treatment and short and long-term outcomes. The study aims to generate real-world evidence on current practices and outcomes to support improvements in national care protocols.

Key facts

Study ID: NCT07027475
Run by: Hospital Israelita Albert Einstein
People needed: 624
Starts: 2026-03-30
Expected to finish: 2027-02-01
Last updated by the study team: 2026-05-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Fever (axillary temperature ≥37.8°C) followed by two or more of the following symptoms: severe headache, vomiting, altered consciousness (confusion, drowsiness, or irritability), photophobia (increased sensitivity to light), presence of seizures OR
Fever accompanied by at least one meningeal irritation sign, such as neck stiffness, Kernig's sign, or Brudzinski's sign OR
Sudden onset of fever and appearance of petechial skin rash or hemorrhagic suffusions

You may not qualify if…

Refusal to provide consent for study participation

Where it is running

Hospital São Vicente de Paulo — Passo Fundo, Rio Grande do Sul, Brazil (enrolling)
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP — Ribeirão Preto, São Paulo, Brazil (enrolling)
Hospital Santa Marcelina — São Paulo, São Paulo, Brazil (enrolling)

Full record on ClinicalTrials.gov

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