Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment

Recruiting now · Not applicable

Conditions studied: Opioid Use Disorder

In brief

The main purpose of this stepped wedge trial will be to test the impact of a bundle of implementation strategies designed to improve ED-outpatient care coordination on long-term buprenorphine retention among adult patients who start buprenorphine for opioid use disorder in a hospital emergency department (ED) and then are referred for continued outpatient buprenorphine treatment after they leave the ED. Our hypothesis is that adopting the bundle of implementation strategies will be associated with subsequent increases in: A) Cumulative number of days with active buprenorphine prescription at 3, 6, and 12 months after patients' initial ED visit (6 months = primary outcome) B) Proportion of patients with active buprenorphine prescriptions without gaps in buprenorphine coverage of more than 7 days at 3, 6, and 12 months after patients' initial ED visit C) Proportion of patients who fill at least 1 outpatient buprenorphine prescription within 30 days of their ED visit D) Clinician reported quality of ED-outpatient care coordination and care transitions

Key facts

Study ID: NCT07024498
Run by: University of California, Davis
People needed: 3492
Starts: 2025-11-01
Expected to finish: 2029-08-01
Last updated by the study team: 2026-06-12

Who can join

Age: 14 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

patients who start buprenorphine for opioid use disorder at a participating ED

Where it is running

Marshall Medical Center Emergency Department — Placerville, California, United States (enrolling)
University of California Davis Emergency Department — Sacramento, California, United States (enrolling)
El Centro Regional Medical Center Emergency Department — El Centro, California, United States
University of California Irvine Emergency Department — Irvine, California, United States

Full record on ClinicalTrials.gov

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