Sigh Ventilation in Cardiac Surgery
Recruiting now · Not applicable
Conditions studied: Postoperative Pulmonary Complications (PPCs), Cardiac Surgery in Adult Patient
In brief
The purpose of this trial is to investigate whether sigh ventilation strategy, combining sigh breaths, low tidal volume, and moderate PEEP levels, protects against major pulmonary complications within the first 7 postoperative days after cardiac surgery, as compared with conventional ventilation strategy with low tidal volume, and moderate PEEP levels.
Key facts
- Study ID
- NCT07024420
- Run by
- Zhongda Hospital
- People needed
- 686
- Starts
- 2025-10-09
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2025-11-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years of age or older;
- Elective cardiac surgery with cardiopulmonary bypass, aortic clamp and cardioplegia;
- Written informed consent is obtained from patients and/or their legal representatives.
You may not qualify if…
- Emergence surgery;
- Left ventricular assist device implantation;
- Planned thoracotomy with one lung ventilation;
- Undergo concurrent surgical procedures outside cardiology;
- Neuromuscular illness;
- Mechanical ventilation within the last 2 weeks before surgery, include CPAP and NIV;
- Preoperative shock;
- Preoperative Hypoxemia (PaO2<60mmHg OR SpO2<90% on ambient air);
- Preoperative left ventricular ejection fraction < 40%;
- Systolic pulmonary artery pressure > 50 mmHg.
Where it is running
- Zhongda Hospital, Southeast University — Nanjing, Jiangsu, China (enrolling)
Full record on ClinicalTrials.gov
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