Effect of Age on PRF Quality; Assessed by Evaluating Healing Outcomes of ARP

Enrolling by invitation · Not applicable

Conditions studied: Healing Wound

In brief

This study will examine whether using PRF and your age are going to affect the healing and regeneration benefits gained from PRF.

Key facts

Study ID

NCT07023757

Run by

University of Michigan

People needed

44

Starts

2025-06-12

Expected to finish

2027-07-01

Last updated by the study team

2026-07-15

Who can join

Age: 20 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age range: 20 to 80 years.
• Patients must require tooth extraction (molars) as a result of caries, periodontal disease, tooth fracture or deemed unrestorable.
• Non-infected sockets with intact buccal bone (≥1.5 mm in thickness measured through calipers)
• Patients interested in implant placement following tooth extraction.

You may not qualify if…

• Allergies or hypersensitivities to study related medications.
• Hematologic disorders/blood dyscrasias.
• Active infectious diseases of any kind.
• Liver or kidney dysfunction/failure.
• Uncontrolled diabetes (HbA1c > 8).
• Active cancer treatment - such as active chemotherapy or radiation therapy.
• Taking medications that will affect their bone healing (for example, bisphosphonates, Long-term NSAIDs use, Steroid).
• Metabolic bone diseases that affect bone healing such as osteoporosis.
• Pregnant or lactating women (self-reported).
• Smoke 10 or more cigarettes per day (self-reported).
• Poor oral hygiene.
• Systemic diseases that compromise the immune system
• Anti-coagulant therapy

Where it is running

• University of Michigan School of Dentistry — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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