Postpartum Evaluation of Nifedipine and Enalapril for Hypertension

Recruiting now · Phase 4

Conditions studied: Hypertension in Pregnancy

In brief

This is an open label, randomized controlled trial designed to compare nifedipine and enalapril in the management of postpartum hypertension. This is an equivalence study- meaning it is not expected one medication is better than the other. Nifedipine has been shown to be better than another common blood pressure medicine, labetalol, for postpartum hypertension but enalapril which is also used worldwide to manage blood pressure postpartum, has not yet been evaluated or compared to nifedipine. Investigators will identify and offer enrollment to women who are admitted for delivery with documented hypertension- participants with either chronic hypertension or pregnancy related hypertension will be included. Our hypothesis is both medications are safe and effective in managing blood pressure and preventing readmission for hypertensive complications during the postpartum period so evaluating the rate of readmission is the primary goal of the study. The only intervention of the trial will be to assign which medication the participant starts taking. Any decisions after that point- stopping medication, changing doses, additional medications, discharge from the hospital, etc, will all be at the discretion of the participant's primary provider.

Key facts

Study ID

NCT07023003

Run by

Nebraska Methodist Health System

People needed

850

Starts

2025-07-11

Expected to finish

2028-12-01

Last updated by the study team

2025-10-22

Who can join

Age: 19 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• admitted for delivery by cesarean or vaginal delivery
• 24 weeks gestation or greater
• Pregnancy related hypertension(HTN) or chronic hypertension. Pregnancy related hypertension will be defined during the study as either a systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg on two occasions at least 4 hours apart. This definition is consistent with the ACOG definition for pregnancy related HTN in patients without CHTN.

You may not qualify if…

• Absolute contraindication to either nifedipine or enalapril Relative contraindications will be reviewed with PI.
• Persistent HR <60 or >110
• Native language other than English

Where it is running

• Methodist Women's Hospital — Omaha, Nebraska, United States (enrolling)

Full record on ClinicalTrials.gov

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