Assessment of Thyroid Dysfunction in Patients Undergoing Haemodialysis at Sohag University Hospital
Recruiting now
Conditions studied: Dialysis; Complications
In brief
Thyroid dysfunction is a prevalent endocrine disorder that significantly impacts the health of patients with chronic kidney disease (CKD), particularly those undergoing dialysis. The prevalence of thyroid dysfunction in dialysis patients has been reported to range from 20% to 60%, highlighting the need for routine screening and management in this vulnerable group (Kuo et al., 2024). Thyroid hormones play a crucial role in regulating various physiological processes, and their dysregulation can lead to complications such as cardiovascular disease, anemia, and impaired quality of life, which are particularly concerning in the dialysis population (Smith et al., 2024). The relationship between CKD and thyroid dysfunction is complex and multifactorial. Uremic toxins can interfere with the hypothalamic-pituitary-thyroid axis, leading to alterations in thyroid hormone production and metabolism. Recent studies have shown that inflammation and oxidative stress associated with CKD can further exacerbate thyroid dysfunction (Johnson et al., 2024). Understanding these mechanisms is essential for developing effective management strategies for thyroid health in dialysis patients.
Key facts
- Study ID
- NCT07022236
- Run by
- Sohag University
- People needed
- 1
- Starts
- 2025-04-13
- Expected to finish
- 2025-10-30
- Last updated by the study team
- 2025-06-15
Who can join
Age: 13 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults aged 18 years and older.
- Patients diagnosed with end-stage renal disease (ESRD) on regular hemodialysis for at least 3 months.
You may not qualify if…
- Known Thyroid Disorders: Patients with a history of thyroid disease (e.g., hypothyroidism, hyperthyroidism) prior to starting dialysis.
- Recent Thyroid Treatment: Patients who have received treatment for thyroid dysfunction (e.g., thyroid hormone replacement, antithyroid medications) within the last six months.
- Patients with acute kidney injury (AKI) or those who are not on regular dialysis.
- Pregnant or lactating women.
- Patients with systemic illnesses or medications that could interfere with thyroid function tests (e.g., corticosteroids, lithium).
Where it is running
- Hospital — Sohag, Egypt (enrolling)
Full record on ClinicalTrials.gov
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