Mild TBI in the Emergency Department

Recruiting now

Conditions studied: Emergency Departments

In brief

Mild TBI is one of the main causes of admission to the Emergency Department (ED). Brain computed tomography (CT) is one of the most widely used diagnostic tools to assess the presence of intracranial lesions. However, in Western countries, 85-95% of CT scans performed in the ED for mild TBI are negative. It is therefore conceivable that a significant number of CTs could be avoided by a more careful use of this exam. On the other hand, excessive use of CT exposes patients to unnecessary radiation, increases healthcare costs and slows down the management of patients in the ED. This study aims to analyze the variability in the use of CT in mild TBI in Italian EDs, validate the scores designed to help the physician decide when to use it and develop a model that predicts the medium-term outcome of patients with mild head trauma.

Key facts

Study ID

NCT07021118

Run by

Mario Negri Institute for Pharmacological Research

People needed

2500

Starts

2026-01-21

Expected to finish

2027-08-31

Last updated by the study team

2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients arriving in the emergency department. Adult patients with mild TBI Adult patients with Glasgow Coma Scale 13-15.

You may not qualify if…

• All patients under 18 years. Patients with trauma-associated loss of consciousness lasting more than 30 minutes.
• Patients with post-traumatic amnesia lasting more than 24 hours.

Where it is running

• Ospedale E. Agnelli Pinerolo — Pinerolo, Italy (enrolling)
• AOU Policlinico San Marco-PO Gaspare Rodolico — Catania, Italy (enrolling)
• Ospedale degli Infermi — Rivoli, Italy (enrolling)
• Istituto Clinico Humanitas — Rozzano, Italy (enrolling)
• Ospedale Madonna del Soccorso — San Benedetto del Tronto, Italy (enrolling)
• Humanitas Gradenigo — Torino, Italy (enrolling)
• Ospedale Carlo Poma — Mantua, Italy (enrolling)
• Ospedale Ca' Foncello — Treviso, Italy (enrolling)
• Ospedale San Bassiano — Bassano del Grappa, Italy (enrolling)
• Ospedale Civile — Voghera, Italy (enrolling)
• ASST Fatebenefratelli Sacco, P.O. Luigi Sacco — Milan, Italy (enrolling)
• Spedali Civili — Brescia, Italy (enrolling)
• Ospedale Unico della Versilia — Camaiore, Italy (enrolling)
• Ente Ospedaliero Cantonale — Lugano, Switzerland
• Ospedale Bentivoglio — Bentivoglio, Italy
• Ospedale degli Infermi — Biella, Italy
• Ospedale Maggiore "CA Pizzardi" — Bologna, Italy
• ASST Ca' Granda Niguarda — Milan, Italy
• Policlinico di Milano Ospedale Maggiore — Milan, Italy
• AOU San Luigi Gonzaga — Orbassano, Italy
• Ospedale Santa Maria delle Croci — Ravenna, Italy
• Ospedale San Giovanni Bosco — Torino, Italy
• Ospedale Michele e Pietro Ferrero — Verduno, Italy
• AOU Ospedale Civile SS.Antonio e Biagio — Alessandria, Italy

Full record on ClinicalTrials.gov

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