Olfactory Biopsies
Recruiting now · Not applicable
Conditions studied: Alzheimer Disease, Smell Loss, Smell Dysfunction
In brief
This research study aims to investigate the function of the olfactory lining in the nasal cavity and its potential alterations in both healthy and diseased conditions. The olfactory lining is involved in the sense of smell. The purpose of this study is to collect tissue from the nasal cavity.
Key facts
- Study ID
- NCT07021040
- Run by
- Duke University
- People needed
- 125
- Starts
- 2025-01-06
- Expected to finish
- 2029-07-31
- Last updated by the study team
- 2026-06-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Between the ages of 18 and 80
- Pre-clinical AD (this cohort consists of subjects who have normal cognitive testing and function, but have positive AD biomarkers);
- Symptomatic AD (a confirmed diagnosis of Alzheimer's or dementia who are capable of understanding and signing the consent document)
You may not qualify if…
- Advanced Alzheimer's/dementia
- Self-reported or known allergy to Afrin or Tetracain HCL (or related class of drugs)
- Active Rhinosinusitis symptoms
- Other known sinonasal disease history that would preclude biopsy (i.e prior sinus or skull base surgery directly impacting this anatomic region, sinonasal neoplasm in this anatomic region, olfactory cleft polyps)
- Parkinson's disease
- Unable or willing to complete the nasal endoscopy procedure.
- Unable to read or speak English
- Unable to provide legally effective consent
- Group 2: Act-seq study or Non-AD controls
- Inclusion Criteria:
- Age 18 years or older
- Patients being seen for rhinology or olfactory disorders
- Patients having unrelated endoscopic nasal surgery
- Exclusion Criteria:
- Self-reported or known allergy to Afrin or Tetracain HCL (or related class of drugs)
- Unable or willing to complete the nasal endoscopy procedure
- Unable to read or speak English
- Unable to provide legally effective consent
Where it is running
- Duke University Health Center — Durham, North Carolina, United States (enrolling)
Full record on ClinicalTrials.gov
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