The Effectiveness of Carbonate Apatite Bone Graft for Alveolar Ridge Preservation

Enrolling by invitation · Not applicable

Conditions studied: Healing Wound

In brief

This study will examine whether the use of synthetic carbon apatite bone graft material will lead to more bone formation compared to human derived allograft and bovine derived xenograft material.

Key facts

Study ID

NCT07020650

Run by

University of Michigan

People needed

45

Starts

2025-06-05

Expected to finish

2027-06-01

Last updated by the study team

2026-03-24

Who can join

Age: 20 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 20 and 80 years old
• Patients requiring tooth extraction (incisors, canines, and premolars) due to caries, periodontal disease, tooth fracture, or unrestorable condition.
• Extraction sockets must be infection-free with dehiscence less than 5mm.
• Patients interested in implant placement after tooth extraction.

You may not qualify if…

• Known allergies or hypersensitivities to medications related to the study (e.g., chlorhexidine)
• Hematologic disorders or blood dyscrasias.
• Active infectious diseases.
• Liver or kidney dysfunction/failure.
• Uncontrolled diabetes (i.e., HbA1c > 8).
• Undergoing active cancer treatment, including chemotherapy or radiotherapy within the last 12 months from the procedure.
• Use of medications affecting bone healing (e.g., bisphosphonates, long-term anti-inflammatory medications).
• Metabolic bone diseases affecting bone healing, such as osteoporosis (self-reported).
• Pregnant or lactating women (self-reported).
• Current smokers of 10 or more cigarettes per day and former smokers who quit less than 10 years ago (self-reported).
• Poor oral hygiene.
• Presence of fenestration defects equal to or greater than 5mm.

Where it is running

• University of Michigan School of Dentistry — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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