POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Postural Orthostatic Tachycardia Syndrome (POTS), Healthy
In brief
This study will describe the interplay between the gut hormones GIP and CCK and their regulation of blood flow to the large vessels in patients with Postural Orthostatic Tachycardia Syndrome (POTS) and GIP, CCK and GLP-1 in healthy. This is addressed by hormone infusions during MR-scans of the abdomen and intake of oral glucose.
Key facts
- Study ID
- NCT07019519
- Run by
- University of Copenhagen
- People needed
- 30
- Starts
- 2025-03-15
- Expected to finish
- 2026-09-30
- Last updated by the study team
- 2025-06-13
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-50
- Waist ratio <180 cm
- Matched a POTS patient in age, sex and BMI
- Exclusion Criteria:
- Chronic illness
- Metallic implants
- Above 10 alcoholic drinks or week or substance abuse
- POTS; other types of sinus tachycardia or heart disease
- Liverenzymes two times above normal values
- Decreased kidney function eGFR <90 or elevated kreatinkinasis
- Thyroid disease or TSH out of reference
- Uncontrollable low or high blood pressure, Orthostatic hypotension
- Blood vessels that cannot be visualized on MR
- Any disease that might influence the health of the participant during the study or participants that receives medicine that cannot be paused for 36 hours
You may not qualify if…
- Chronic illness
- Metallic implants
- Above 10 alcoholic drinks or week or substance abuse
- Other types of sinus tachycardia or heart disease
- Liverenzymes two times above normal values
- Decreased kidney function eGFR <90 or elevated kreatinkinasis
- Thyroid disease or TSH out of reference
- Uncontrollable low or high blood pressure
- Blood vessels that cannot be visualized on MR
- Any disease that might influence the health of the participant during the study or participants that receives medicine that cannot be paused for 36 hours
- Inclusion Criteria:
- Age 18-50
- Waist ratio <180 cm
- Matched a POTS patient in age, sex and BMI
- Exclusion Criteria:
- Chronic illness
- Metallic implants
- Above 10 alcoholic drinks or week or substance abuse
- POTS; other types of sinus tachycardia or heart disease
- Liverenzymes two times above normal values
- Decreased kidney function eGFR <90 or elevated kreatinkinasis
- Thyroid disease or TSH out of reference
- Uncontrollable low or high blood pressure, Orthostatic hypotension
- Blood vessels that cannot be visualized on MR
- Any disease that might influence the health of the participant during the study or participants that receives medicine that cannot be paused for 36 hours
Where it is running
- Rigshospitalet — Copenhagen, Denmark (enrolling)
Full record on ClinicalTrials.gov
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