Addressing Emotional Distress in Dyads of Persons With a Young Onset Dementia (YOD) and Their Care-partners

Recruiting now · Not applicable

Conditions studied: Young Onset Dementia

In brief

The purpose of the present investigation is to test the efficacy of a virtual, brief (6 sessions) dyadic (patient and care-partner together) intervention to prevent chronic emotional distress in dyads where one person is diagnosed with Young Onset Dementia (YOD). Through this study, we seek to address the unmet need of preventing chronic emotional distress in YOD dyads through a feasible, acceptable and credible program, and ideally enhance resiliency and improve wellbeing and quality of life in both members of the dyad.

Key facts

Study ID

NCT07018726

Run by

Massachusetts General Hospital

People needed

388

Starts

2026-01-28

Expected to finish

2031-01-01

Last updated by the study team

2026-04-15

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Between the ages of 18-65 at the time of enrollment [both patient and care-partner]
• Diagnosis of young-onset dementia (FTD, PPA, AD, PCA, etc.) with symptom onset prior to age 65 [patient]
• A designated care-partner willing and interested to participate [both patient and care-partner]
• Received YOD diagnosis in the past 6 month [patient]
• English fluency and literacy [both patient and care-partner]
• Cognitive ability to understand study and research protocol in order to consent to study participation per referring neurologist [both patient and care-partner]
• Patient and/or caregiver exhibit emotional distress on screening (using HADS D and/or HADS A scores > 7)

You may not qualify if…

• An additional, terminal diagnosis such as cancer
• Lack of access to internet and/or a device with a camera
• Current untreated or unstable severe mental health conditions like bipolar disorder, schizophrenia, or active substance use

Where it is running

• Massachusetts General Hospital (MGH) — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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