Intrapatient Comparison of STN and GPi tTIS in PD

Enrolling by invitation · Not applicable · Has a placebo group

Conditions studied: Parkinson Disease

In brief

The goal of this clinical trial is to investigate the therapeutic efficacy of tTIS in patients with Parkinson's disease and to evaluate the immediate effects and conduct intrapatient comparisons of individualized 130 Hz Subthalamic Nucleus-transcranial Temporal Interference Stimulation (STN-tTIS) and Globus Pallidus Internus-transcranial Temporal Interference Stimulation (GPi-tTIS) on motor symptoms in patients with early to mid-stage Parkinson's Disease (PD) during "off" medication states. The main questions this study aims to answer are: 1. Can tTIS significantly improve the motor symptoms of patients with Parkinson's disease? 2. Is the therapeutic effect of STN-tTIS superior to that of GPi-tTIS?

Key facts

Study ID

NCT07018388

Run by

Ruijin Hospital

People needed

100

Starts

2025-04-23

Expected to finish

2026-11-01

Last updated by the study team

2026-04-22

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of primary Parkinson's disease (MDS);
• Hoehn \& Yahr stage ≤ 3;
• Antiparkinsonian drugs must have remained unchanged in the past four weeks, and the dosage must have remained stable throughout the study.

You may not qualify if…

• Presence of neurological disorders that may affect the study (e.g., traumatic brain injury);
• Antipsychotics, antidepressants, or dopamine modulators outside of PD drugs;
• Metal devices in the head or heart (e.g., deep brain stimulators, pacemakers);
• Unstable vital signs.

Where it is running

• Ruijin Hospital — Shanghai, Shanghai Municipality, China

Full record on ClinicalTrials.gov

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