Expression of Genes Relating Hypertension and Efficacy of 4-7-8 Breathing Control on Reducing Blood Pressure
Recruiting now · Not applicable
Conditions studied: Genetic Predisposition to Disease, Breathing, Mouth
In brief
This study consists of two sub-studies. Study 1 investigates gene expression related to the development of hypertension in Thailand, and Study 2 examines the effectiveness of the 4-7-8 breathing technique in reducing blood pressure in individuals with hypertension.
Key facts
- Study ID
- NCT07018128
- Run by
- Burapha University
- People needed
- 200
- Starts
- 2024-10-01
- Expected to finish
- 2026-09-30
- Last updated by the study team
- 2026-05-11
Who can join
Age: 18 and older, up to 59. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Male or female
- Aged between 18-59 years
- Of Thai ethnicity
- Diagnosed with hypertension, defined as having an SBP of 140 mmHg or higher, or a DBP of 90 mmHg or higher, or having previously been diagnosed with hypertension and currently taking antihypertensive medication
- Originally from various regions of Thailand and currently residing in the eastern region
You may not qualify if…
- Has heart disease, such as valvular stenosis or regurgitation, coronary artery disease, or heart failure
- Has obesity, defined as having a body mass index (BMI) of 30 kg/m² or higher
- Has a fever or is currently experiencing an infectious disease, such as COVID-19, the flu, or other infections
- Group of individuals with normal blood pressure
- Inclusion Criteria:
- Male or female
- Aged between 18-59 years
- Of Thai ethnicity
- Does not have hypertension, defined as having an SBP below 130 mmHg and a DBP below 85 mmHg, with no prior diagnosis of hypertension and no history of taking antihypertensive medication
- Originally from various regions of Thailand and currently residing in the eastern region
- Exclusion Criteria:
- Has heart disease, such as valvular stenosis or regurgitation, coronary artery disease, or heart failure
- Has obesity, defined as having a body mass index (BMI) of 30 kg/m² or higher
- Has a fever or is currently experiencing an infectious disease, such as COVID-19, the flu, or other infections
- Study 2:
- Inclusion Criteria:
- Male or female, aged 35-59 years
- Diagnosed with hypertension, with blood pressure levels above the normal range, defined as SBP of 130 mmHg or higher, or DBP of 85 mmHg or higher, and currently taking medication
- Originally from various regions of Thailand and currently residing in the eastern region
- Able to communicate effectively
- Exclusion Criteria:
- Has respiratory diseases, cardiovascular diseases, cerebrovascular disease, kidney disease, cancer, or immune-related conditions such as allergies, autoimmune diseases (e.g., SLE), immunodeficiency, or rheumatoid arthritis
- Is obese, defined as having a body mass index (BMI) of 30 kg/m² or higher
- Has a fever or is currently infected, such as with COVID-19, the flu, or other infectious diseases
- Is currently pregnant, breastfeeding, or has a history of pregnancy within the 6 months prior to participating in the study
Where it is running
- Faculty of Allied Health Sciences, Burapha University — MueangChonburi, Changwat Chon Buri, Thailand (enrolling)
Full record on ClinicalTrials.gov
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