Correlation Between Serum Uric Acid, Serum Homocysteine Level and Interleukin- 17 in Lupus Nephritis Patients
Recruiting now
Conditions studied: Homocysteine Level and Interleukin- 17 in Lupus Nephritis Patients
In brief
Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystem autoimmune disease characterized by pathogenic autoantibodies production against nuclear structures . SLE affecting mainly women of childbearing age and is characterized by unpredictable flares and remissions. Disease severity varied from a mild episodic disorder to a rapidly progressive life-threatening illness. The kidney is the most commonly involved visceral organ in SLE. Therefore, identifying new noninvasive biomarkers of LN severity and outcome is mandatory. IL-17 is a potent pro-infammatory cytokine that amplifes T-cell activation and stimulates fibroblast cells, endothelial, and epithelial cells to produce several pro-infammatory mediators, including IL-1β, IL-6, and TNF-α. IL-17 receptor signaling enhances the expression of multiple pro-infammatory mediators. Hence, IL-17 enhances the production of neutrophil-attracting chemokines
Key facts
- Study ID
- NCT07017868
- Run by
- Sohag University
- People needed
- 120
- Starts
- 2025-01-01
- Expected to finish
- 2026-04-01
- Last updated by the study team
- 2025-06-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- ● Aged ≥18 years.
- SLE patients fulfilling the SLE International Collaborating Clinics (SLICC) classification criteria and matched controls.
- Patients cooperative and can answer questions.
- Patients who are able and willing to give written informed consent
You may not qualify if…
- ● Individuals with other autoimmune diseases.
- Patients receive any hyperuricemia treatment
- Pregnancy
- Malignancy
- Diabetes.
- Hypertension.
- Heart failure.
- Hepatic diseases.
- Chronic renal failure other than lupus nephritis.
- Renal artery stenosis.
- Renal vein thrombosis.
- Intrarenal arteriovenous fistula.
- Obstructive nephropathy.
- Urinary tract obstruction that could affect RI of intra renal arteries.
- Uncooperative patients.
- Patients not able and willing to give written informed consent.
Where it is running
- Sohag university Hospital — Sohag, Egypt (enrolling)
Full record on ClinicalTrials.gov
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