REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Venous Thromboembolism (VTE)
In brief
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing Venous Thromboembolism (VTE) and other related diseases after total knee replacement surgery. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)
Key facts
- Study ID
- NCT07015905
- Run by
- Regeneron Pharmaceuticals
- People needed
- 2000
- Starts
- 2025-06-25
- Expected to finish
- 2027-05-12
- Last updated by the study team
- 2026-07-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Shoals Medical Trials, Inc. — Sheffield, Alabama, United States (enrolling)
- CARI Clinical Trials — Riverside, California, United States (enrolling)
- Denver Metro Orthopedics, P.C. Englewood Location — Englewood, Colorado, United States (enrolling)
- Delray Physician Care Center — Delray Beach, Florida, United States (enrolling)
- Bioresearch Partner — Miami, Florida, United States (enrolling)
- Sacred Heart Health System Inc — Pensacola, Florida, United States (enrolling)
- Gulfcoast Research Institute — Sarasota, Florida, United States (enrolling)
- Phoenix Clinical Research — Tamarac, Florida, United States (enrolling)
- Sinai Hospital of Baltimore, Inc. — Baltimore, Maryland, United States (enrolling)
- Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)
- Curalta Clinical Trials — Westwood, New Jersey, United States (enrolling)
- Duke University Health System (Duke Health), Duke University Hospital — Durham, North Carolina, United States (enrolling)
- Keystone Clinical Studies LLC, dba Flourish Research — Plymouth Meeting, Pennsylvania, United States (enrolling)
- HD Research - First Surgical Hospital — Bellaire, Texas, United States (enrolling)
- University of Texas (UT); Southwestern Medical Center — Dallas, Texas, United States (enrolling)
- NextStage Clinical Research, All American Orthopedics and Sports Medicine — Houston, Texas, United States (enrolling)
- Futuro Clinical Trials — McAllen, Texas, United States (enrolling)
- Flourish Research - San Antonio (Formerly Clinical Trials of Texas) — San Antonio, Texas, United States (enrolling)
- DRx Clinical Research, LLC; South Texas Bone and Joint Institute — San Antonio, Texas, United States (enrolling)
- DRx Clinical Research, LLC — St. George, Utah, United States (enrolling)
- Multi-profile Hospital for Active Treatment Hearth and Brain EAD — Pleven, Bulgaria (enrolling)
- Multiprofile Hospital for Active Treatment; Sveta Sofia EOOD (MBAL Sveta Sofia), — Sofia, Bulgaria (enrolling)
- University Multiprofile Hospital for Active Treatment "Prof. Dr. Stoyan Kirkovich" — Stara Zagora, Bulgaria (enrolling)
- Szegedi Tudomanyegyetem; Albert Szent-Gyorgyi Clinical Center — Szeged, Csongrad-Csanad, Hungary (enrolling)
- Gyor-Moson-Sopron Varmegyei Egyetemi Oktato Korhaz — Győr, Győr-Moson-Sopron, Hungary (enrolling)
Full record on ClinicalTrials.gov
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