Treatment of Complex Post-traumatic Stress Disorder Among Displaced People in Switzerland and Germany

Recruiting now · Not applicable

Conditions studied: Complex Post-Traumatic Stress Disorder

In brief

In WHO ICD-11 (its latest edition), the diagnostic criteria for post-traumatic stress disorder (PTSD) were revised, and a new sibling disorder, complex post-traumatic stress disorder (CPTSD) was introduced. CPTSD is a debilitating condition associated with severe, prolonged, or chronic trauma. Refugee populations are affected by high prevalence of CPTSD because of high rates of such trauma (e.g. torture). Untreated CPTSD has negative consequences for quality of life and for integration into the host society. Evidence indicates cultural variation in the phenomenology of CPTSD. Modular approaches, e.g., the Skills Training in Affective and Interpersonal Regulation combined with Modified Prolonged Exposure (ESTAIR/MPE), have been recommended for the treatment of CPTSD. However, they have not been tested in a clinical trial among refugees so far and there are no available publications about their effectiveness in CPTSD symptom reduction among this population. Research suggests a higher symptom reduction of trauma-focused techniques, such as Narrative Exposure Therapy (NET), among refugee population. In a previous study, the investigators pilot tested a version of ESTAIR/NET that was adapted to sociocultural and structural aspects related to psychopathology in refugee populations. The performance of these culturally adapted modules in CPTSD symptom reduction among the refugee population remains to be assessed. The present clinical trial seeks to assess the effect of the culturally adapted modules of the ESTAIR manual on symptom reduction among refugees and asylum seekers diagnosed with CPTSD.

Key facts

Study ID: NCT07015567
Run by: Eva Heim
People needed: 288
Starts: 2026-01-21
Expected to finish: 2030-12-01
Last updated by the study team: 2026-07-31

Who can join

Age: 17 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Informed consent signature
Refugees and asylum seekers with a valid residence permit (N, F, B, or C status)
Speaking Arabic, Farsi/Dari, Pashtu, Kurdish (different dialects), Turkish, English, German, or French
Originating from Middle East, Northern Africa, or Sub-Sahara Africa
A psychotherapy is indicated and was prescribed
Participated to part 1 of the study and was diagnosed with CPTSD on the basis of the standard International Trauma Interview and the Socio-cultural and structural addendum (SCSA). The diagnosis is done based on the clinical judgement by the local therapist.

You may not qualify if…

Acute psychosis
Imminent risk of suicide
Severe alcohol and/or substance abuse
Being enrolled in another psychotherapy
Inability to follow study procedures (i.e., cognitive impairment)
Inability to give informed consent
Known pregnancy

Where it is running

Appartenances - CPM Yverdon-les-Bains — Yverdon-les-Bains, Canton of Vaud, Switzerland (enrolling)
Integrierten Psychiatrie Winterthur — Winterthur, Canton of Zurich, Switzerland (enrolling)
Psy4Asyl — Aarau, Canton of Aargau, Switzerland (enrolling)
UPK Transkulturelle Ambulanz — Basel, Canton of Basel-City, Switzerland (enrolling)
Psychiatrie Basel-Land — Liestal, Basel-Landschaft, Switzerland (enrolling)
Appartenances - CPM Lausanne — Lausanne, Canton of Vaud, Switzerland (enrolling)
SRK Ambulatorium für Folter- und Kriegsopfer — Wabern, Canton of Bern, Switzerland
Centra — Hamburg, Free and Hanseatic City of Hamburg, Germany

Full record on ClinicalTrials.gov

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