Assessment of Drug Liking In Peri-procedural Clinical Settings
Enrolling by invitation · Early Phase 1 · Has a placebo group
Conditions studied: Drug Liking
In brief
The purpose of this study is to evaluate whether medications used in peri-procedural clinical settings can modulate drug liking.
Key facts
- Study ID
- NCT07015528
- Run by
- Stanford University
- People needed
- 130
- Starts
- 2025-09-30
- Expected to finish
- 2027-08-31
- Last updated by the study team
- 2026-05-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- American Society of Anesthesiologists (ASA) physical status classification of I, II or III
- Candidates who are expected to receive fentanyl up to 3 mcg/kg IBW for their scheduled for surgery or procedure
You may not qualify if…
- Craniofacial abnormalities
- Known or suspected difficult intubation or mask ventilation
- Known or suspected need for rapid sequence induction and intubation
- Allergies or hypersensitivities to droperidol or fentanyl
- Clinically significant pulmonary disease, such as chronic obstructive lung disease requiring long-term oxygen therapy, or other conditions that, in the study team's judgment, may increase the risk of severe respiratory depression with opioid administration
- History of long QT syndrome
- History of Torsades de Pointes
- History of psychosis
- History of movement disorders e.g. Parkinson's Disease
- Past chronic use of anti-psychotics
- Current use of droperidol, levodopa, lithium, clozapine, metoclopramide, benzodiazepines
- Current use of opioids
- History of opiate abuse within the last 3 years
- Known or suspected severe chronic pain condition that require use of opiates or limit daily activities
- History of pheochromocytoma
- History of concomitant prolactin-dependent tumors e.g. prolactinoma, breast cancer
- Pregnancy or nursing
- Current use of antiemetic medication (i.e., 5HT or dopamine antagonists)
- Active seizure disorder
- Active mental health disorders resulting in functional impairment
- Current use of psychostimulant medications (Adderall)
- Current use of CNS depressants (e.g., barbiturates, benzodiazepines)
- Severe renal insufficiency (Stage 4 or 5)
- Impaired cognitive function
- Regular Cannabis use (2+ times per week)
Where it is running
- Stanford Hospital — Palo Alto, California, United States
Full record on ClinicalTrials.gov
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