Precision Analytic Research Methods in OCD

Recruiting now · Not applicable

Conditions studied: Obsessive Compulsive Disorder

In brief

Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. Compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. This study will recruit 100 individuals (50 adults diagnosed with OCD, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (EEG) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.

Key facts

Study ID

NCT07011901

Run by

Icahn School of Medicine at Mount Sinai

People needed

100

Starts

2025-07-09

Expected to finish

2030-03-31

Last updated by the study team

2025-10-23

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants must be:
• between the ages 18-55 years old
• English-speaking
• right-handed
• able to provide consent

You may not qualify if…

• Individuals diagnosed with OCD will be excluded if:
• they meet diagnostic criteria for certain other psychiatric disorders
• are taking psychiatric medication or have received behavioral treatment for OCD within a certain timeframe
• if it is unsafe for them to participate in research
• Healthy control participants will be excluded if:
• they have a current psychiatric disorder
• a lifetime history of certain psychiatric disorders
• are taking psychiatric medication or have in the past
• have a parent or sibling who has been diagnosed with OCD
• if it is unsafe for them to participate in research

Where it is running

• Icahn School of Medicine at Mount Sinai — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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