Dynamic Treatment Regimes for Opioid Use Disorder

Starting soon · Phase 2

Conditions studied: Opioid Use Disorder

In brief

This study aims to develop and evaluate dynamic treatment regimes (DTRs) to improve personalized care for individuals with opioid use disorder (OUD). Using machine learning methods and longitudinal data from a national behavioral health provider, the investigators will identify optimal treatment sequences that minimize the risk of overdose and improve recovery outcomes. A pilot hybrid factorial SMART trial will be conducted to assess the feasibility and acceptability of implementing these personalized treatment decision rules in real-world clinical settings.

Key facts

Study ID

NCT07011758

Run by

Brigham and Women's Hospital

People needed

75

Starts

2028-07-01

Expected to finish

2030-06-01

Last updated by the study team

2025-11-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 or older
• Diagnosed with opioid use disorder (OUD)
• Receiving care at a participating Discovery Behavioral Health site
• Able to provide informed consent

You may not qualify if…

• Significant cognitive impairment or psychiatric instability that would prevent participation
• Current incarceration or involuntary commitment

Where it is running

• Discovery Behavioral Health — Irvine, California, United States

Full record on ClinicalTrials.gov

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