A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)
Recruiting now · Phase 2
Conditions studied: Colon Cancer, Rectal Cancer, Colorectal Cancer, Colorectal Cancer (CRC)
In brief
This is an open-label multicenter, single-arm Phase II study of Fruquintinib in combination with FOLFIRI (leucovorin calcium (folinic acid), fluorouracil, and irinotecan) in participants with metastatic colorectal cancer (mCRC). The main goals of this study are to: * Evaluate the efficacy of the combination of fruquintinib + FOLFIRI in the 2nd-line mCRC setting * Evaluate the safety of the combination of fruquintinib + FOLFIRI
Key facts
- Study ID
- NCT07011576
- Run by
- SCRI Development Innovations, LLC
- People needed
- 60
- Starts
- 2025-09-29
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-06-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Rocky Mountain Cancer Center - Primary — Denver, Colorado, United States (enrolling)
- Illinois Cancer Specialists — Arlington Heights, Illinois, United States (enrolling)
- Maryland Oncology Hematology — Columbia, Maryland, United States (enrolling)
- Minnesota Oncology Hematology - Primary — Maple Grove, Minnesota, United States (enrolling)
- Missouri Cancer Associates — Columbia, Missouri, United States (enrolling)
- Oncology Associates of Oregon - Primary — Eugene, Oregon, United States (enrolling)
- Northwest Cancer Specialists - Compass — Portland, Oregon, United States (enrolling)
- Alliance Cancer Specialists — Wynnewood, Pennsylvania, United States (enrolling)
- SCRI Oncology Partners — Nashville, Tennessee, United States (enrolling)
- Texas Oncology - Central/South Texas — Austin, Texas, United States (enrolling)
- Texas Oncology - Gulf Coast — Beaumont, Texas, United States (enrolling)
- Texas Oncology - Northeast Texas — Tyler, Texas, United States (enrolling)
- Virginia Oncology Associates — Norfolk, Virginia, United States (enrolling)
- Blue Ridge Cancer Care (Oncology & Hematology Associates of Southwest VA) — Salem, Virginia, United States (enrolling)
Full record on ClinicalTrials.gov
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