Investigation of the Effect of Horizontal Platelet Rich Fibrin Placed in Tooth Extraction Sockets on Bone Formation

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Conditions studied: Tooth Loss, Dental Implant Failed, Alveolar Bone Loss

In brief

Dental implants, the treatment of complete and partial edentulous cases involving the restoration of lost teeth, have become a registered and widely used treatment option. Implants: It is an ideal option for the good oral health of the person who has lost his teeth due to periodontal disease, caries, trauma, or any other reason. When teeth are missing, melting occurs in the jawbone. Following tooth extraction, the loss of the implant and the amount of melting are significantly reduced. In implant treatments, which have become widely used today, successful results depend on the ideal volume and quality of hard and soft tissues. The amount of bone present in the edentulous area is important for the indication of the implant. The aim of this study is to evaluate the histological and immunohistochemical contribution of the H-PRF (horizontal-platelet rich fibrin) material placed in the extraction sockets to the quality of the newly formed bone tissue in order to make successful implants after tooth extractions for various reasons in humans. The research hypothesis is that H-PRF will contribute positively to the healing of tooth extraction sockets.

Key facts

Study ID

NCT07011303

Run by

Tokat Gaziosmanpasa University

People needed

30

Starts

2024-06-01

Expected to finish

2026-04-01

Last updated by the study team

2026-01-26

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Volunteer ASA I individuals between the ages of 18-40
• Individuals with indication for tooth extraction
• Patients who want to have implants after tooth extraction

You may not qualify if…

• Those who are pregnant or lactating
• Those receiving anticoagulant or antiplatelet drug therapy
• Those who received radiotherapy to the head and face area

Where it is running

• Tokat Gaziosmanpasa University, Faculty of Dentistry — Tokat Province, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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