A Study of Treatment-Related Toxicities and Quality of Life After Local Therapy in Chinese Breast Cancer Patients
Recruiting now
Conditions studied: Breast Neoplasms, Quality of Life (QOL), Toxicities, Breast Diseases
In brief
This study, called PERSEVERE, examines how local treatment for early breast cancer affects people's health and daily lives over time. People who join the study will have early-stage breast cancer and receive treatment such as surgery and other therapies that are used before or after surgery. The study does not include people with late-stage (metastatic) breast cancer. Researchers want to learn about short- and long-term side effects that can happen during or after treatment. These may include tiredness, trouble sleeping, emotional distress, pain, or changes in heart or lung function. The study also looks at how these effects impact participants' quality of life. Participants will be asked to complete surveys about how they feel. They will also have health checks, such as heart tests, lung function tests, and blood samples. Tissue samples from surgery will also be collected. The goal is to understand better how different people respond to breast cancer treatment and find ways to support long-term recovery.
Key facts
- Study ID
- NCT07010939
- Run by
- FangYi
- People needed
- 3000
- Starts
- 2025-04-07
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2025-09-12
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Women aged 18 years or older
- Diagnosed with stage I, II, or III invasive breast cancer confirmed by pathology or cytology
- No signs of metastatic disease (cancer that has spread to other parts of the body)
- Scheduled to receive local treatment, including:
- Surgery
- And/or neoadjuvant or adjuvant therapy such as chemotherapy, radiation, hormone therapy, or targeted therapy
- Willing and able to complete health questionnaires and attend follow-up visits
- Has given written informed consent to join the study
You may not qualify if…
- Have metastatic breast cancer or local recurrence
- Have already received curative treatment (surgery, chemo, etc.) for the current breast cancer before joining the study
- Are currently pregnant or breastfeeding
- Have a history of another cancer within the past 5 years (except for non-melanoma skin cancer or in-situ cervical cancer)
- Are unable to participate in the study due to mental, physical, or legal reasons (for example, under legal guardianship or imprisonment)
Where it is running
- National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College — Beijing, Beijing Municipality, China (enrolling)
- Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center — Shenzhen, Guangdong, China
- Shanxi Cancer Hospital — Taiyuan, Shanxi, China
Full record on ClinicalTrials.gov
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