Treatment Decision-Making Among Patients With Chronic Rhinosinusitis

Enrolling by invitation · Not applicable

Conditions studied: Chronic Rhinosinusitis (CRS)

In brief

This project aims to develop and pilot-test a bilingual, patient-centered clinical decision support (PC CDS) web application for individuals with chronic rhinosinusitis (CRS), a condition affecting 16% of U.S. adults annually and significantly impacting quality of life. While endoscopic sinus surgery (ESS) is a recommended treatment for medically refractory cases, many patients experience barriers that lead to surgical hesitancy. Prior research at USC revealed significant disparities in ESS uptake (Odds Ratio = 7.92; 95% Confidence Interval: 2.95-21.28), highlighting the need for more tailored decision support. The PC CDS will include educational resources, Large Language Model-assisted patient narratives, and a provider communication module to facilitate shared decision-making (SDM). The study has three aims: (1) to develop the tool; (2) to evaluate its feasibility in a randomized controlled trial with 50-60 patients from USC clinics; and (3) to assess outcomes using surveys and interviews. Participants will be randomized into either a control group (receiving standard CRS informational handouts) or an intervention group (receiving standard care plus the PC CDS tool). Quantitative surveys will measure treatment choice, decision quality, SDM involvement, CRS knowledge, provider trust, and care satisfaction. Qualitative interviews will explore participants' healthcare journeys and experiences with the tool. Guided by experts in health technology and rhinology and in collaboration with a Patient Advisory Group, the study aims to ensure patient-centered design and lay the groundwork for future implementation and external funding (e.g., AHRQ).

Key facts

Study ID

NCT07010679

Run by

University of Southern California

People needed

50

Starts

2025-06-02

Expected to finish

2026-06-01

Last updated by the study team

2025-12-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older
• Patient receiving care at a USC otolaryngology clinic located in Los Angeles, Glendale, La Cañada, or Arcadia
• Diagnosis of chronic rhinosinusitis (CRS) as defined by the American Academy of Otolaryngology-Head and Neck Surgery criteria
• Medically refractory CRS (i.e., persistent symptoms despite appropriate medical therapy)
• Considered a candidate for endoscopic sinus surgery (ESS) by the treating otolaryngologist
• English- or Chinese-speaking
• Able and willing to provide informed consent
• Access to a smartphone, tablet, or computer with internet connection

You may not qualify if…

• Not offered endoscopic sinus surgery (ESS) as a treatment option by the treating otolaryngologist

Where it is running

• Keck Medicine of USC — Arcadia, California, United States

Full record on ClinicalTrials.gov

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