Epithelial Dysmetabolism and Renal Fibrosis in ANCA Vasculitis

Recruiting now

Conditions studied: ANCA Associated Vasculitis, Extramembranous Glomerulopathy, Nephrotic Syndrome, Minimal Change, Interstitial Nephritis, IgA Nephropathy, Segmental Hyalinosis, Diabetic Nephropathies

In brief

The project is to explore in humans the hypothesis of the link between the alteration of tubulo-interstitial metabolism and the rate of deterioration of renal function by comparing various nephropathies.

Key facts

Study ID: NCT07010250
Run by: Assistance Publique - Hôpitaux de Paris
People needed: 146
Starts: 2025-11-03
Expected to finish: 2029-11-02
Last updated by the study team: 2026-06-30

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients with an indication for initial diagnostic PBR on native kidney
18 ans ≥ Age ≤ 90 ans
Affiliation to french health insurance
Patient having given consent
For the ANCA vasculitis group:
Diagnosis of ANCA vasculitis retained on renal biopsy with ANCA anti-proteinase 3 (PR3) or ANCA anti-myeloperoxidase (MPO)
For the control groups:
Diagnosis retained after the renal biopsy
Interstitial Nephritis
Or glomerular nephropathy such as minimal change nephropathy
Or Segmental hyalinosis in itscollapsing form
Or Extramembranous Glomerulopathy,
Or glomerulopathy with mesangial IgA deposits
Or diabetic nephropathy.

You may not qualify if…

Kidney transplant patient
Patient on dialysis (hemodialysis or peritoneal dialysis)
Patient under legal protection, guardianship or curatorship
Pregnancy or breastfeeding
Enrollement in an interventional study except studies relating to ANCA vasculitis and nephropathy with mesangial IgA deposits.

Where it is running

Georges-Pompidou European Hospital, AP-HP — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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