Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children

Recruiting now

Conditions studied: Acute Appendicitis, Acute Appendicitis With Rupture, Abdominal Pain (AP)

In brief

Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery. Prostaglandin E urinary metabolites (PGE-M) have been found elevated in various inflammatory conditions, but their diagnostic value in pediatric appendicitis is not well established. This study aims to assess the potential of PGE-M as a biomarker for acute appendicitis in children. The study will be conducted over 12 months and will include 100 children aged 5 to 17 years presenting with acute abdominal pain. In addition to routine laboratory tests, urinary PGE-M levels will be analyzed. The study involves minimal risk to participants

Key facts

Study ID

NCT07008092

Run by

KBC Split

People needed

100

Starts

2025-06-02

Expected to finish

2026-05-01

Last updated by the study team

2025-06-06

Who can join

Age: 5 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• children of age 5 -17 years with acute abdominal pain
• children with clinical signs of acute appendicitis

You may not qualify if…

• previous diagnosis of chronic and/or malignant disease
• children who had previous abdominal surgery
• pregnancy

Where it is running

• University Hospital of Split — Split, Croatia (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.