Initial Feasibility Study of the STENTiT Resorbable Fibrillated Scaffold (RFS). The RFS is Intended to Restore Lumen Patency and Blood Flow to Infrapopliteal Arteries. The RFS is a Fully Electrospun Tubular Device With a Fibrillated Microarchitecture and Designed for Transcatheter Delivery

Recruiting now · Not applicable

Conditions studied: Critical Limb Ischemia (CLI)

In brief

This is the First-In-Human feasibility study of the RFS for below the knee lesions in subjects who experience critical limb ischemia due to the peripheral artery disease. The aim of this study is to investigate if the RFS can be implanted safely and with technical success. Up to 10 subjects will be treated with the RFS at one investigational site. Lesions within the inflow trajectory or side branches may be treated with institutions standard of care prior to treatment of the target lesion. This may include usage of POBA, BMS, DCB, or DES. The target lesion will be predilated with POBA. Device safety will be assessed throughout the clinical investigation, with primary safety endpoints defined as freedom from Major Adverse Limb Events (MALE) at 30 days follow-up. In addition, MALE at 3-, 6-, 12-, and 24- months follow-up, all adverse events, serious adverse events and all device deficiencies will be captured as secondary endpoints. Device performance will be based on technical success of the implantation defined as successful delivery and deployment with a residual area stenosis of ≤50% as determined on final perioperative IVUS. Primary patency at day of discharge, 30-days, 3-, 6-, 12-, and 24- months follow up will be captured as secondary performance endpoint and are based on duplex ultrasound for all timepoints and angiography and IVUS at 6-months follow-up.

Key facts

Study ID

NCT07006467

Run by

Stentit

People needed

10

Starts

2025-06-03

Expected to finish

2027-08-31

Last updated by the study team

2025-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• General inclusion criteria:
• Subject must provide written informed consent prior to any clinical investigation related procedures.
• Subject is willing and able to comply with the study procedures, and follow-up schedule.
• Subject has Critical Limb Ischemia (CLI), Rutherford Becker Clinical Category 4 or 5
• Subject must be at least 18 years of age.
• Anatomical inclusion criteria:
• Target lesion located in the tibioperoneal trunk, or 2/3 proximal part of the anterior tibial artery, posterior tibial artery or peroneal artery.
• Only one target lesion per subject is included, other lesions can be treated per institution's standard of care.
• At least one infrapopliteal branch without an angiographic significant lesion (≥50% diameter stenosis by angiography).
• Vessel diameter of 3.0 mm to 3.4 mm. Quantitative imaging (IVUS and angiography) will be used to aid accurate sizing of the vessels.
• Target lesion length ≤ 18 mm.
• Target lesion of ≥70% diameter stenosis, per angiographic assessment at the time of the procedure.
• Target lesion is in an area that may be stented without blocking access to subject main branches, i.e ≥2 mm distanced from any bifurcation.
• Successful antegrade crossing of the target lesion

You may not qualify if…

• General exclusion criteria:
• Subject is currently participating in another clinical investigation that has not yet reached the primary endpoint.
• Pregnant or nursing subjects or with planned pregnancy during the clinical investigation follow-up period.
• Presence of other anatomic or comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements.
• Incapacitated individuals, as defined as persons who are mentally ill, mentally handicapped, or individuals without legal authority, are excluded from the study population.
• Subject has known hypersensitivity or contraindication to device material and its degradants (poly (L-lactide), poly (glycolic acid), lactic acid, and glycolic acid) that cannot be adequately pre-medicated. Subject has known contrast sensitivity that cannot be adequately pre-medicated.
• Subject has known allergy hypersensitivity or contraindication to aspirin; or to ADP antagonists such clopidogrel, prasugrel or ticagrelor; or to anticoagulants such as heparin or bivalirudin, and therefore cannot be adequately treated with study medications.
• Subject with planned surgery or procedure necessitating discontinuation of antiplatelet medications, within 3 months after index procedure.
• Subject has life expectancy ≤ 1 year.
• Subject has had a stroke within the previous 3 months with residual Rankin score of ≥2.
• Subject has renal insufficiency as defined as an estimated GFR < 30ml/min per 1.73m2
• Subject has platelet count < 100,000 cells/mm3 or > 700,000 cells/mm3, a WBC < 3,000 cells/mm3, or hemoglobin < 9.0 g/dl.
• Subject has known serious immunosuppressive disease (e.g. human immunodeficiency virus), or has severe autoimmune disease, that requires chronic immunosuppressive therapy (e.g. systemic lupus erythematosus, etc.), or subject is receiving immunosuppression therapy for other conditions. Subjects treated for HIV (Human Immunodeficiency Virus) and who have undetectable viral load, such that their immune system is not considered compromised, are eligible.
• Subject has Body Mass Index (BMI) < 18.
• Subject has a known coagulation disorder with increased risk of arterial thrombosis. Subject with deep vein thrombosis and disorders that increase the risk of deep vein thrombosis can be included in the study.
• Subject who requires thrombolysis as a primary treatment modality or requires other treatment for acute limb ischemia of the target limb.
• Subject has previously had or requires surgical revascularization involving any vessel of the ipsilateral extremity.
• Subject has signs or symptoms of advanced limb infection or septicemia (fever > 38.5 degrees Celsius, WBC > 15,000 cells/microliter, hypotension) at the time of assessment.
• Subject with extensive tissue loss salvageable only with complex foot reconstruction or non-traditional transmetatarsal amputation.
• Anatomic exclusion criteria:
• Subject has tandem lesions at the target lesion site (plaque free zone < 2 cm)
• Pre-dilatation of the target lesion at the time of study intervention did not reach <50% residual diameter stenosis by angiography.
• Target lesion that has prior metallic stent implant.
• Failed PTA of target lesion ≤ 60 days prior to the procedure date.
• The target vessel has another significant lesion (≥50% diameter stenosis by angiography).

Where it is running

• Medical Universiteit Graz — Graz, Austria (enrolling)

Full record on ClinicalTrials.gov

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