THUMB: Multi-centre Cluster Trial for Caesarean Section Haemorrhage

Recruiting now · Not applicable

Conditions studied: Postpartum Hemorrhage

In brief

The quality improvement project evaluating the delivery of a perioperative care complex intervention to improve haemorrhage-related outcomes in patients undergoing caesarean section. The objectives of the current study will be: 1. To evaluate whether implementation of the 'Rule of THUMB' perioperative complex intervention increases risk assessment, diagnosis and compliance with proven interventions for haemorrhage during and after caesarean section. 2. To understand the influence of contextual and socio-dynamic factors on how the trial results were achieved and how the intervention mechanisms did, or did not, work in practice (the process evaluation). The findings from this study will be used subsequently to modify and improve the quality improvement intervention, so that it can be delivered at scale across Africa and assess its impact on haemorrhage during and after caesarean section in the future.

Key facts

Study ID

NCT07005349

Run by

Bruce Biccard

People needed

2400

Starts

2025-06-01

Expected to finish

2026-06-30

Last updated by the study team

2026-04-13

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Any patient who requires a caesarean section in participating countries with hospitals that routinely perform caesarean section.

You may not qualify if…

• Patients who opt out of the trial will be excluded.

Where it is running

• Mowbray Maternity Hospital — Cape Town, South Africa (enrolling)

Full record on ClinicalTrials.gov

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