Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostomized Patients Receiving Prolonged Mechanical Ventilation

Recruiting now

Conditions studied: Weaning Failure

In brief

This project focuses on the analysis of the correlation between transpulmonary driving pressure and uneven lung ventilation and regional lung compliance in patients using prolonged mechanical ventilation (PMV), in order to understand the clinical occurrence of failure of the final spontaneous breathing test and inability to breathe. Respiratory physiology impairments in patients successfully discharged from respirators.

Key facts

Study ID

NCT07003672

Run by

National Taiwan University Hospital

People needed

120

Starts

2025-01-16

Expected to finish

2028-06-30

Last updated by the study team

2025-06-04

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Post-tracheostomy patients who are transferred to the subacute respiratory care ward of National Taiwan University Hospital must use respirators for at least 14 days;
• Be at least 20 years old;
• The oxygen concentration required when using the respirator does not exceed 50%

You may not qualify if…

• The vital signs are unstable or require continuous use of vasopressors;
• Pregnancy;
• Chronic obstructive pulmonary disease or asthma;
• Those who have contraindications to the placement of esophageal pressure balloons, such as abnormal blood coagulation, esophageal varices, and those who have undergone esophageal or gastric surgery in the past six months;
• Those who have contraindications to the use of electrical impedance tomography, such as heart rhythm regulators.

Where it is running

• National Taiwan University Hospital — Taipei, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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