Reperfusion Treatment in Acute Pulmonary Embolism
Recruiting now
Conditions studied: Pulmonary Embolism
In brief
International guidelines recommend immediate reperfusion with systemic thrombolysis (ST) as first-line treatment in high-risk pulmonary embolism (PE). The therapy improves hemodynamics and overall survival but is also associated with a significant risk of severe bleeding. Catheter-directed intervention (CDI) is recommended as an alternative reperfusion therapy in high-risk PE when ST is contraindicated or has failed, as well as in patients who deteriorate or fail to improve during anticoagulation (AC) treatment. Despite lack of high-quality evidence and randomized studies between CDI and standard care, the use of CDI is spreading rapidly in high-risk PE and in less severe PE not fulfilling current treatment criteria.
Key facts
- Study ID
- NCT07003646
- Run by
- Sahlgrenska University Hospital
- People needed
- 220
- Starts
- 2025-04-01
- Expected to finish
- 2029-05-01
- Last updated by the study team
- 2026-01-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All adult patients (≥18 years), including pregnant women, with verified (CTPA, angiography or scintigraphy) acute pulmonary embolism who are planned for, or have received, treatment with catheter directed intervention or systemic thrombolysis
- Informed consent (for patients who do not survive before informed consent can be obtained, a waiver of consent applies)
You may not qualify if…
- Ongoing enrolment in interventional catheter directed intervention trial
- Surgical embolectomy as primary reperfusion treatment
Where it is running
- Aarhus University Hospital — Aarhus, Denmark (enrolling)
- Rigshospitalet — Copenhagen, Denmark (enrolling)
- Odense University Hospital — Odense, Denmark (enrolling)
- Sahlgrenska University Hospital — Gothenburg, Sweden (enrolling)
- Linköping University Hospital — Linköping, Sweden (enrolling)
- Sunderby Hospital — Luleå, Sweden (enrolling)
- Skåne University Hospital — Lund, Sweden (enrolling)
- Örebro University Hospital — Örebro, Sweden (enrolling)
- Danderyd Hospital — Stockholm, Sweden (enrolling)
- Karolinska University Hospital Huddinge — Stockholm, Sweden (enrolling)
- Karolinska University Hospital Solna — Stockholm, Sweden (enrolling)
- Södersjukhuset — Stockholm, Sweden (enrolling)
- Uppsala University Hospital — Uppsala, Sweden
Full record on ClinicalTrials.gov
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