Ischemic Preconditioning in Osteoarthritis and Back Pain

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Low Back Pain, Knee Osteoarthritis

In brief

We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.

Key facts

Study ID

NCT07003113

Run by

University of Illinois at Chicago

People needed

24

Starts

2025-09-12

Expected to finish

2026-12-31

Last updated by the study team

2025-11-17

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Reported Knee Pain using ACR Criteria
• Reported Back Pain using ODI Criteria > 12
• Ability to walk for at least 3 minutes without the use of aids
• Ability to provide written informed consent

You may not qualify if…

• Younger than 50 years old
• History of Knee or Hip Replacements
• History of steroid injection within the previous 6 months
• Presence of neuromuscular joint condition that affects lower extremity function
• History of blood clots in the leg or any condition in which compression of the thigh is contraindicated
• History of heart failure or thrombosis
• Allergic to ultrasound gel
• History of spine surgery
• Non-English speaker
• Currently pregnant or intends to become pregnant during the study

Where it is running

• Human and Sport Performance Lab — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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