A Study to Evaluate the Efficacy, Safety, and Tolerability in Participants With Obesity or Overweight With Weight-Related Comorbidities

Completed · Phase 2 · Has a placebo group

Conditions studied: Chronic Weight Management

In brief

This randomized, double-blind, placebo-controlled phase IIa study is designed to evaluate the efficacy, safety, and tolerability of ASC30 Tablets and ASC30 Tablets A1.

Key facts

Study ID

NCT07002905

Run by

Ascletis Pharma (China) Co., Limited

People needed

125

Starts

2025-07-03

Expected to finish

2025-12-08

Last updated by the study team

2025-12-15

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have provided informed consent before initiation of any study-specific procedures.
• Male or female participants, non-smokers, between 18 and 75 years of age (both inclusive).
• No clinically significant findings from medical history, physical examination, 12-lead ECG, vital signs measurements, and other screening procedures.

You may not qualify if…

• Have evidence of any clinically significant active or chronic disease.
• Have any prior diagnosis of diabetes mellitus (T1DM or T2DM), or rare forms of diabetes mellitus.
• Have an autoimmune disease, is immunosuppressed or is in any way immunocompromised.
• Have a history of acute or chronic pancreatitis.
• Participants with a known clinically significant gastric emptying abnormality.
• Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy.
• Have a history of any other condition (such as known drug or alcohol abuse, diagnosed eating disorder, or other psychiatric disorder) that, in the opinion of the Investigator, may preclude the participant from following and completing the protocol.

Where it is running

• Ascletis Clinical Site — Rogers, Arkansas, United States
• Ascletis Clinical Site — Fort Myers, Florida, United States
• Ascletis Clinical Site — Miami, Florida, United States
• Ascletis Clinical Site — Columbus, Ohio, United States
• Ascletis Clinical Site — Bellaire, Texas, United States
• Ascletis Clinical Site — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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