Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients

Recruiting now

Conditions studied: Intestinal Ischemia, Critical Illness, Enteral Nutrition Feeding, Hemodynamics, Ultrasonography, Doppler

In brief

This study aims to address the challenges of enteral nutrition support in critically ill ICU patients with varying gastrointestinal function. We'll use bedside Doppler ultrasound to monitor superior mesenteric artery (SMA) blood flow changes post - feeding, exploring its correlation with Acute Gastrointestinal Injury (AGI) and other hemodynamic indicators. Our goals are to identify the patterns of SMA blood flow changes, establish a predictive model linking SMA blood flow reactivity to AGI risk, and propose individualized enteral nutrition strategies based on intestinal hemodynamics. Through this innovative approach, we hope to enhance the safety of enteral nutrition, reduce AGI incidence, and improve patient outcomes.

Key facts

Study ID

NCT07001943

Run by

Peking Union Medical College Hospital

People needed

80

Starts

2025-06-01

Expected to finish

2026-07-01

Last updated by the study team

2025-09-05

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged ≥18 years and ≤80 years.
• Admitted to the study with a expected stay of more than 72 hours.
• Require initiation of enteral nutrition support.

You may not qualify if…

• Pre-existing severe gastrointestinal diseases.
• Patients with gastrointestinal bleeding.
• Patients with bowel obstruction.
• Pregnant or lactating women.
• Patients with contraindications to bedside Doppler ultrasound.

Where it is running

• Peking union medical college hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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