Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell Patients

Recruiting now

Conditions studied: Sickle Cell, Sickle Cell Disease, Vaso-Occlusive Crises

In brief

Sickle cell disease is a chronic disease characterized by multiple vaso-occlusive complications. The basic treatment for patients with a vaso-occlusive crisis (VOC) is based on adequate hydration, oxygen therapy and pain control. Loco Regional Anesthesia (LRA) is one of the major treatments in resuscitation anesthesia for both anesthesia and analgesia. LRA allows effective and almost immediate pain control by blocking nerve afferents in a given area. LRA could decrease the inflammatory response during crises and accelerate resolution of the crisis.

Key facts

Study ID

NCT07001189

Run by

Centre Hospitalier Universitaire de la Guadeloupe

People needed

34

Starts

2025-02-05

Expected to finish

2027-02-05

Last updated by the study team

2025-06-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients adult >18 years
• patients with vaso-occlusive crisis

You may not qualify if…

• Pregnant or breastfeeding women
• Blood transfusion within the last 3 months
• Lack of affiliation with the French social security system
• Protected individuals

Where it is running

• Chu de La Guadeloupe — Pointe-à-Pitre, Guadeloupe (enrolling)

Full record on ClinicalTrials.gov

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