Imaging Studies in Corticobasal Syndrome

Recruiting now

Conditions studied: Cortico Basal Degeneration, Corticobasal Syndrome, Corticobasal Syndrome(CBS), Corticobasal Degeneration, Corticobasal Degeneration (CBD), Corticobasal Syndrome (CBS)

In brief

The primary goal of this study is to investigate inflammation and white matter damage in corticobasal syndrome and determine whether these processes are related to each other. The investigator's will address our goal by using neuroimaging and blood plasma biomarkers, as well as molecular pathology.

Key facts

Study ID

NCT07000851

Run by

Jennifer Whitwell

People needed

80

Starts

2025-06-25

Expected to finish

2031-03-30

Last updated by the study team

2026-07-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 years or older
• Meet possible or probable CBS criteria

You may not qualify if…

• Subjects will be excluded if MRI is contraindicated (due to implanted device, severe claustrophobia, etc)
• Subjects will be excluded if they have a concurrent illnesses or structural abnormality that could account for the CBS syndrome
• Subjects will be excluded if they have a mutation in the progranulin gene
• Subjects will excluded if they have received anti-Aβ therapy
• Women who are pregnant will be excluded
• Subjects will be excluded if they are actively taking daily anti-inflammatory medications (NSAIDs, corticosteriods, etc)
• Subjects will be excluded if they have generalized inflammatory condition and treatment with immunosuppressive, corticoid/glucocorticoid, steroidal or non-steroidal anti-inflammatory medication within 2 weeks of scanning

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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