Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass
Recruiting now
Conditions studied: Postoperative Cognitive Dysfunction, Delirium, Postoperative
In brief
Neurological dysfunction either transient or permanent is a major cause of morbidity and mortality after cardiopulmonary bypass, and cognitive dysfunction is more frequent in cardiac surgery than in non-cardiac procedures. Variations in cerebral blood flow and oxygen extraction are considered key contributing factors. Although pulsatile flow during bypass has shown benefits for renal function and recovery, its effects on postoperative neurological dysfunction and delirium remain unclear due to limited research. This study aims to evaluate the impact of pulsatile versus non-pulsatile cardiopulmonary bypass flow on POCD in adult CABG patients by measuring middle cerebral artery (MCA) flow using transcranial Doppler.
Key facts
- Study ID
- NCT07000461
- Run by
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
- People needed
- 106
- Starts
- 2025-04-17
- Expected to finish
- 2026-04-30
- Last updated by the study team
- 2026-02-17
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged 18-70
- Patients scheduled for isolated elective cardiopulmonary bypass surgery
You may not qualify if…
- Patients with carotid stenosis ≥50%
- Emergency patients or those with a history of reoperation
- Patients with a history of cerebrovascular events
- Patients who do not provide consent
- Patients with temporal window failure
- Patients with an ejection fraction (EF) <40%
- Patients with a Mini-Mental State Examination (MMSE) score <23
- Patients who require mechanical ventilation for more than 24 hours or those who are reintubated
Where it is running
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital — Istanbul, Turkey (Türkiye) (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.