Quadriceps Motor Unit Adaptation to Simulated Knee Injury

Recruiting now · Early Phase 1 · Has a placebo group

Conditions studied: Muscle Inhibition, Knee Injury Simulation

In brief

This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.

Key facts

Study ID

NCT06999057

Run by

University of Central Florida

People needed

45

Starts

2026-08-01

Expected to finish

2027-08-01

Last updated by the study team

2026-05-01

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-30 years
• Physically active (Tegner ≥ 5)
• No prior lower-limb surgery or major injury

You may not qualify if…

• Lower limb surgery or significant injury in past 2 years
• Cardiopulmonary, neurological, or psychiatric disorders
• Needle/electrical stimulation anxiety
• Medications affecting neuromuscular or psychological function
• Pregnancy
• Allergic to lidocaine
• Inability to elicit Hoffmann reflex

Where it is running

• University of Central Florida — Orlando, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.