Sodium in the Skin and Atopic Dermatitis
Recruiting now
Conditions studied: Eczema, Atopic Dermatitis
In brief
The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above. The study is designed to test whether diet and skin barrier function are associated with skin sodium concentration and whether skin sodium concentration is linked to atopic dermatitis and immune profiles over time. Participants will be asked to complete questionnaires, provide bio samples, and undergo non-contrast sodium MRI at 2-3 time points over 3-24 months.
Key facts
- Study ID
- NCT06998446
- Run by
- University of California, San Francisco
- People needed
- 90
- Starts
- 2025-05-12
- Expected to finish
- 2028-08-30
- Last updated by the study team
- 2026-07-14
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ages 50 years and above
- Willing to undergo non-contrast MRI (e.g., no contraindications to MRI, such as cardiac pacemakers, non-compatible intracranial vascular clips or pregnancy).
You may not qualify if…
- History of autoimmune disease.
- Cardiac events in the last six months.
- Impaired function of the liver or kidneys (glomerular filtration rate <60ml/min).
- Current use of medications that influence sodium excretion (e.g. thiazide diuretics, SGLT2 inhibitors and spironolactone), and/or chemotherapy or antibiotic treatment.
- Currently receiving phototherapy or taking systemic medications for atopic dermatitis including cyclosporine, methotrexate, or other broad immunosuppressive medications.
- (Patients on dupilumab will not be excluded if they have been on dupilumab for at least two months and still meet the criteria for severe disease.)
Where it is running
- San Francisco VA Medical Center — San Francisco, California, United States (enrolling)
- UCSF Mt Zion Campus — San Francisco, California, United States (enrolling)
Full record on ClinicalTrials.gov
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