Digitally Rendered Interventions And Knowledge To Limit Ethanol-Associated Atrial Fibrillation Severity

Recruiting now · Not applicable

Conditions studied: Atrial Fibrillation (AF)

In brief

Per the 2021 National Survey on Drug Use and Health administered by the U.S. Department of Health and Human Services, 85% of all American adults consume alcohol. Atrial fibrillation (AF) is the most common arrhythmia, affecting more than 10 million individuals in U.S., comprising 4.5% of the adult population. Although alcohol abstinence clearly reduces AF in heavy drinkers, observational data comparing the health effects of limited consumption versus abstention are conflicting. The Mediterranean diet is one of the few that has demonstrated clear cardiovascular benefits in a randomized study-this diet allows for the consumption of red wine (or high polyphenol/ low alcohol alcohol), generally not more than one drink in 24 hours, with meals, avoiding spirits and binge drinking. The effect of the "Mediterranean drinking pattern" on AF risk compared to alcohol abstinence remains unknown. This single center, randomized, controlled trial aims to compare the effects of a digital health intervention to encourage durable alcohol abstinence versus allowing guideline-adherent moderate alcohol consumption on AF severity. The knowledge gained from this study may be used to determine optimal thresholds for alcohol use among AF patients.

Key facts

Study ID

NCT06995391

Run by

University of California, San Francisco

People needed

1000

Starts

2025-04-20

Expected to finish

2030-03-01

Last updated by the study team

2025-07-31

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Are age 21 years or older
• Have a smartphone
• Are able to use the Eureka mobile application
• Have a history of paroxysmal or persistent atrial fibrillation (AF)
• Have consumed alcohol at least once per month on average in the past year
• Willing to receive messaging encouraging alcohol abstinence

You may not qualify if…

• Non-english speaker
• Currently pregnant or trying to get pregnant
• A healthcare professional's instruction to avoid alcohol (for any reason)
• Currently incarcerated
• Permanent AF (meaning a medical determination has been made that sinus rhythm would definitely never be pursued in this patient)
• Are unable to read or sign to provide informed consent

Where it is running

• UCSF Medical Center at Parnassus — San Francisco, California, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.