A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes
Running, not enrolling · Phase 3 · Has a placebo group
Conditions studied: Obesity, Overweight, Type 2 Diabetes
In brief
The purpose of this Master Protocol is to support two studies to see how well and how safely orforglipron works compared to placebo in participants who have obesity or overweight with or without type 2 diabetes. Participants will be screened for about 4 weeks, after which they will enroll into either J2A-MC-GZP1, NCT06972459 (do not have type 2 diabetes) or J2A-MC-GZP2, NCT06972472 (have type 2 diabetes).
Key facts
- Study ID
- NCT06993792
- Run by
- Eli Lilly and Company
- People needed
- 1400
- Starts
- 2025-05-15
- Expected to finish
- 2027-08-01
- Last updated by the study team
- 2026-07-31
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Novak Clinical Research - Tucson - North La Cholla Boulevard — Tucson, Arizona, United States
- Norcal Endocrinology & Internal Medicine — San Ramon, California, United States
- Southern California Clinical Research — Santa Ana, California, United States
- Care Access - Thousand Oaks — Thousand Oaks, California, United States
- Accel Research Sites - DeLand Clinical Research Unit — DeLand, Florida, United States
- Innovation Medical Research Center - Fort Lauderdale — Fort Lauderdale, Florida, United States
- Indago Research & Health Center, Inc — Hialeah, Florida, United States
- Encore Medical Research — Hollywood, Florida, United States
- West Orange Endocrinology P.A. — Ocoee, Florida, United States
- Care Access - Tampa — Tampa, Florida, United States
- Conquest Research — Winter Park, Florida, United States
- Accel Research Sites - NeuroStudies Clinical Research Unit — Decatur, Georgia, United States
- Care Access - Decatur — Decatur, Georgia, United States
- Javara - Privia Medical Group Georgia - Savannah — Savannah, Georgia, United States
- North Georgia Clinical Research — Woodstock, Georgia, United States
- Solaris Clinical Research — Meridian, Idaho, United States
- Care Access - New Iberia — New Iberia, Louisiana, United States
- Endocrine and Metabolic Consultants — Rockville, Maryland, United States
- Javara - Privia Medical Group - Silver Spring — Silver Spring, Maryland, United States
- Great Lakes Research Group, Inc. — Bay City, Michigan, United States
- Boeson Research MSO — Missoula, Montana, United States
- Javara - Nevada Health Centers - Carson City — Carson City, Nevada, United States
- The Machuca Foundation — Las Vegas, Nevada, United States
- University of North Carolina Medical Center — Chapel Hill, North Carolina, United States
- Clinical Research Institute of Arizona (CRI) - Sun City West — Sun City West, Arizona, United States
Full record on ClinicalTrials.gov
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